Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate passions consist of:
Our team experiments bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our primary interest lies in mobile division, chromatin construction, and spatial Manage.
‘It was simply just a subject of selecting up a guide on mobile biology and beginning to study. I had originate from a planet of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Operating at home temperature with molecular biology kits.
Non-equilibrium folding of unique DNA molecules recaptured nearly a thousand situations inside of a good point out nanopore
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style in 2005. (nl)
SMC complexes can go Bodily roadblocks bigger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement within the molecular and mobile stage. Our jobs involve the subsequent:
Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation
In 1993, as a younger and keen affiliate professor at Delft College of Technologies, I'd in the beginning focused the analysis initiatives of my team on measuring the electrical conductance of just one conducting-polymer molecule. In two decades, we had developed a tool wherein just one wire of a phthalocyaninepolysiloxane polymer was linked between two closely spaced steel nanoelectrodes.
But carbon nanotubes have remained a research topic of considerable fascination to a lot of. Indeed, the outlook on using carbon nanotubes to make simple equipment, https://www.ceesdekker.net in parts for instance radio-frequency electronics, electronic electronics and flexible electronics, remains bright.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
‘That concerns the synthetic mobile, as A part of the Dutch BaSyC initiative. Craig Venter seemed top-down in People times and identified about five hundred genes which have been minimally necessary for just a working mobile. We wish to search base-up: how can we move from a couple molecules to a complete biological process?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
Finally, I will briefly sketch some of our Tips to check out the making of synthetic cells, particularly our initial measures to ascertain synthetic cell division.